Associate Scientist or Scientist - Yen Lab/Therapeutic Genome Engineering (TGEn Group)

• Perform studies to develop genome editing strategies for human hematopoietic stem cells (HSC).


• Design and execute IND-enabling experiments to characterize the pharmacology of a genome-edited human hematopoietic stem cell product to treat sickle cell disease.


• Characterize the efficacy, safety, and potency of the HSC cellular drug product in in vitro and xenotransplantation assays.


• Multicolor flow cytometry and FACS to sort hematopoietic populations of relevance.


• Develop experimental methods including RT-PCR, ddPCR, next-generation sequencing, and single-cell sequencing.


• Perform NGS library preparation and analysis of editing outcomes, on-target and off-target.


• Evaluate scale-up and close-system processes to ensure reproducibility of the drug product.


• Conduct exploratory research on developing novel in-vitro and in-vivo delivery strategies.


• Interact and collaborate with multidisciplinary teams to advance the program.


• Establish tracking and trending analyses of process development and pilot runs.


• Draft documentation (protocols, batch records, reports) to standardize and transfer process to GMP facility.


• Maintains regular and predictable attendance.


• Performs other related duties as assigned to meet the goals of the department and institution.

• Bachelor's degree in a relevant scientific area is required.


• Master's or PhD degree in a relevant scientific area is highly preferred.

• 7 + years of research experience is required


• 5 + years of research experience is required with a Master's degree


• 2 + years of research experience is required with a PHD


• Experience leading and supporting research experiments preferred


• Some experience leading lab and scientific project coordination, maintenance, and other research support activities preferred


• Experience in guiding and training other laboratory personnel preferred


• Proven performance in earlier role/comparable role

• Eight (8) years of relevant post-degree work experience is required with a Bachelor's degree.


• Six (6) years of relevant post-degree work experience is required with a Master's degree.


• Three (3) years of relevant post-degree work experience is required with a PhD.


• Experience leading and supporting research experiments preferred.


• Some experience leading lab and scientific project coordination, maintenance, and other research support activities preferred.


• Experience in guiding and training other laboratory personnel preferred.


• Proven performance in earlier role/comparable role.